Publication

 

Endothelial CCRL2 induced by disturbed flow promotes atherosclerosis via chemerin-dependent β2 integrin activation in monocytes.

Cardiovasc Res Aug 07, 2023

Author(s):

• Chaojun Tang
• Guona Chen
• Fan Wu
• Yiren Cao
• Fei Yang
• Tao You
• Chu Liu
• Menglu Li
• Shuhong Hu
• Lijie Ren
• Qiongyu Lu
• Wei Deng
• Ying Xu
• Guixue Wang
• Hanjoong Jo
• Yonghong Zhang
• Yi Wu
• Brian A Zabel
• Li Zhu

Abstract:
Chemoattractants and their cognate receptors are essential for leucocyte recruitment during atherogenesis, and atherosclerotic plaques preferentially occur at predilection sites of the arterial wall with disturbed flow (d-flow). In profiling the endothelial expression of atypical chemoattractant receptors (ACKRs), we found that Ackr5 (CCRL2) was up-regulated in an endothelial subpopulation by atherosclerotic stimulation. We therefore investigated the role of CCRL2 and its ligand chemerin in atherosclerosis and the underlying mechanism.