Endothelial CCRL2 induced by disturbed flow promotes atherosclerosis via chemerin-dependent β2 integrin activation in monocytes.
Cardiovasc Res Aug 07,
2023
Author(s):
Chaojun Tang
Guona Chen
Fan Wu
Yiren Cao
Fei Yang
Tao You
Chu Liu
Menglu Li
Shuhong Hu
Lijie Ren
Qiongyu Lu
Wei Deng
Ying Xu
Guixue Wang
Hanjoong Jo
Yonghong Zhang
Yi Wu
Brian A Zabel
Li Zhu
Abstract:
Chemoattractants and their cognate receptors are essential for leucocyte recruitment during atherogenesis, and atherosclerotic plaques preferentially occur at predilection sites of the arterial wall with disturbed flow (d-flow). In profiling the endothelial expression of atypical chemoattractant receptors (ACKRs), we found that Ackr5 (CCRL2) was up-regulated in an endothelial subpopulation by atherosclerotic stimulation. We therefore investigated the role of CCRL2 and its ligand chemerin in atherosclerosis and the underlying mechanism.