Chemerin-Derived Peptide Val-Pro Is Effective in Limiting Methicillin-Resistant Skin Infection.

Front Microbiol , 2021

  • Aneta Zegar
  • Urszula Godlewska
  • Dorota Kozłowska-Chmielewska
  • Pawel Majewski
  • Brian A Zabel
  • Joanna Cichy

Chemerin-derived peptide Val-Pro (p4) restricts the growth of a variety of skin-associated bacteria, including methicillin-resistant (MRSA). To better understand the antimicrobial potential of chemerin peptide, we compared p4 activity against MRSA to cathelicidin LL-37, one of the key endogenous peptides implicated in controlling the growth of . The efficacy of p4 was also validated in relevant experimental models of skin pathology, such as topical skin infection with community-acquired MRSA, and in the context of skin inflammatory diseases commonly associated with colonization with , such as atopic dermatitis (AD). We showed that p4 collaborates additively with LL-37 in inhibiting the growth of , including MRSA, and that p4 was effective in reducing MRSA burden. p4 was also effective in reducing levels of skin-infiltrating leukocytes in -infected AD-like skin. Taken together, our data suggest that p4 is effective in limiting and, in particular, MRSA skin infection.


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