Activation of CXCR2 by extracellular matrix degradation product acetylated Pro-Gly-Pro has therapeutic effects against sepsis.
Am J Respir Crit Care Med Jul 15,
2011
Author(s):
Sang Doo Kim
Ha Young Lee
Jae Woong Shim
Hak Jung Kim
Young Hyun Yoo
Joon Seong Park
Suk-Hwan Baek
Brian A Zabel
Yoe-Sik Bae
Abstract:
Acetylated Pro-Gly-Pro (Ac-PGP) is an endogenous degradation product of extracellular collagen that binds to leukocyte-expressed chemoattractant receptor CXCR2. Although certain agents that block CXCR2-mediated signaling protect against experimental sepsis, the roles of Ac-PGP and CXCR2 in sepsis are unclear.
