Activation of CXCR2 by extracellular matrix degradation product acetylated Pro-Gly-Pro has therapeutic effects against sepsis.

Am J Respir Crit Care Med Jul 15, 2011

  • Sang Doo Kim
  • Ha Young Lee
  • Jae Woong Shim
  • Hak Jung Kim
  • Young Hyun Yoo
  • Joon Seong Park
  • Suk-Hwan Baek
  • Brian A Zabel
  • Yoe-Sik Bae

Acetylated Pro-Gly-Pro (Ac-PGP) is an endogenous degradation product of extracellular collagen that binds to leukocyte-expressed chemoattractant receptor CXCR2. Although certain agents that block CXCR2-mediated signaling protect against experimental sepsis, the roles of Ac-PGP and CXCR2 in sepsis are unclear.


View this publication on PubMed